Journal
BIOMARKERS
Volume 16, Issue 2, Pages 136-143Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2010.536256
Keywords
Nestin; SOX-2; brain tumour
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Funding
- Helmholtz Society [NT-GE-016+062]
- Verein zur Forderung der Krebsforschung in Deutschland
- Bundesministerium fur Bildung und Forschung [01GS0886]
- Tumorzentrum Heidelberg-Mannheim
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Both markers were expressed abundantly and staining of nestin significantly increased with WHO grade. Further, nestin and Sox-2 immunoreactivity was significantly associated with tumour cell proliferation and nestin expression was independently associated with poor patient survival. Our findings suggest that immature glioma cells are involved in tumour growth and tumour progression and significantly impact on patient prognosis.
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