Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 270, Issue 3, Pages 761-765Publisher
ACADEMIC PRESS INC
DOI: 10.1006/bbrc.2000.2505
Keywords
tyrosine kinase; PYK2; H2O2; reactive oxygen species; vascular smooth muscle cell; angiotensin II
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Funding
- NHLBI NIH HHS [HL58205, HL03320] Funding Source: Medline
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In vascular smooth muscle cells (VSMCs), the focal adhesion kinase-related tyrosine kinase PYK2/CAK beta is activated by vascular mitogens, Because reactive oxygen species (ROS) are assumed to mediate mitogenic signals by these agonists, we examined the possible link between ROS and PYK2 in cultured rat VSMCs. Here we present several lines of evidence showing that PYK2 is activated by ROS in VSMCs. The inhibitory effect of an antioxidant, N-acetyl-cysteine, on PYK2 activation by its specific agonists further suggests the pivotal role of PYK2 in vascular remodeling associated with enhanced ROS production. (C) 2000 Academic Press.
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