Journal
BIOMARKERS
Volume 16, Issue 7, Pages 590-599Publisher
INFORMA HEALTHCARE
DOI: 10.3109/1354750X.2011.611598
Keywords
Biomarkers; CYP2E1; dermal exposure; glutathione S-transferase mu 1 (GSTM1); glutathione S-transferase theta 1 (GSTT1); jet fuel (JP-8); keratin adduct; NAD(P) H:quinone oxidoreductase (NQO1); 1-naphthol; 2-naphthol; naphthalene; urine
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Funding
- NIEHS [P42ES05948]
- National Institute for Occupational Safety and Health (NIOSH) [T42/CCT422952, T42/008673]
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We investigated the association between biomarkers of dermal exposure, naphthyl-keratin adducts (NKA), and urine naphthalene biomarker levels in 105 workers routinely exposed to jet-fuel. A moderate correlation was observed between NKA and urine naphthalene levels (p = 0.061). The NKA, post-exposure breath naphthalene, and male gender were associated with an increase, while CYP2E1*6 DD and GSTT1-plus (++/+-) genotypes were associated with a decrease in urine naphthalene level (p < 0.0001). The NKA show great promise as biomarkers for dermal exposure to naphthalene. Further studies are warranted to characterize the relationship between NKA, other exposure biomarkers, and/or biomarkers of biological effects due to naphthalene and/or PAH exposure.
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