Journal
BIOMARKERS
Volume 16, Issue 2, Pages 181-191Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2010.543289
Keywords
Disease progression; CART analysis; serum
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Funding
- National Institute for Occupational Safety and Health [R01-OH04192, R01-OH07590]
- National Institute of Environmental and Health Sciences [2 P01 ES011810]
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Methods: SELDI-TOF and CART were used to identify serum biomarker profiles in 35 asbestosis patients who subsequently developed cancer and 35 did not develop cancer. Results: Three polypeptide peaks (5707.01, 6598.10, and 20,780.70 Da) could predict the development of cancer with 87% sensitivity and 70% specificity. The first two peaks were identified as KIF18A and KIF5A, respectively, and are part of the Kinesin Superfamily of proteins. Conclusions: We identified two Kinesin proteins that can be potentially used as blood biomarkers to identify asbestosis patients at risk of developing lung cancer.
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