Journal
BIOMARKERS
Volume 16, Issue 6, Pages 517-524Publisher
INFORMA HEALTHCARE
DOI: 10.3109/1354750X.2011.604133
Keywords
Heavy metal toxicity; neurological disease; environmental pollution/ecotoxicology
Categories
Funding
- NIEHS [R01-ES013744, RO1 ES014930]
- Agency for Toxic Substances and Disease Registry (ATSDR)
- U.S. Environmental Protection Agency (EPA)
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Objective: To find the best lead exposure assessment marker for children. Methods: We recruited 11 children, calculated a cumulative blood lead index (CBLI) for the children, measured their concurrent BLL, assessed their development, and measured their bone lead level. Results: Nine of 11 children had clinically significant neurodevelopment problems. CBLI and current blood lead level, but not the peak lead level, were significantly or marginally negatively associated with the full-scale IQ score. Conclusion: Lead exposure at younger age significantly impacts a child's later neurodevelopment. CBLI may be a better predictor of neurodevelopment than are current or peak blood lead levels.
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