Journal
BIOMARKERS
Volume 16, Issue 1, Pages 83-88Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2010.533285
Keywords
cohort studies; metabonomics; nested design; metabolic profiles; intermediate biomarkers
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Funding
- European Union [226756]
- Biotechnology and Biological Sciences Research Council [Ref.BB/E20372/1]
- Biotechnology and Biological Sciences Research Council [BB/E020372/1] Funding Source: researchfish
- Medical Research Council [G0801056B, G0801056] Funding Source: researchfish
- BBSRC [BB/E020372/1] Funding Source: UKRI
- MRC [G0801056] Funding Source: UKRI
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Background: Predictive disease risk biomarkers that can be linked to exposure have proved difficult to identify in case-control studies. Methods: Parallel statistical analysis of the correlation between H-1 NMR profiles from plasma samples collected before disease onset (EPIC cohort), versus exposure to dietary compounds, and follow-up disease endpoints (colon and breast cancer) was performed. Results: Metabonomic signatures associated with colon cancer and dietary fiber intake (a protective factor according to epidemiological studies) were identified. Conclusion: This implementation of the novel meet-in-the-middle analytical strategy indicates how case-control studies nested in prospectively collected cohorts may reveal intermediate biomarkers linking exposure and disease.
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