Journal
BIOMARKERS
Volume 15, Issue 8, Pages 671-676Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2010.510580
Keywords
Growth differentiation factor 15; heart failure; biomarkers
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Funding
- National Basic Research Program of the PR China [2007cb512107]
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Identification of individuals in the early stage of heart failure (HF) may allow earlier initiation of disease-modifying treatment. We evaluated concentrations of the growth differentiation factor (GDF)-15at different stages and its potential screening value in 208 subjects. Plasma GDF-15 was measured by using an enzyme-linked immunosorbent assay. GDF-15 was positively correlated with the stages of HF (r=0.804, p < 0.001). In distinguishing patients with stage B HF, the area under the curve was 0.873 (p < 0.001). These findings indicate that GDF-15 concentration was elevated with the progressing stages of HFand might have potential screening implications for stage B HF.
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