Journal
BIOMARKERS
Volume 16, Issue 1, Pages 89-96Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2010.533287
Keywords
Acrylonitrile; 2-cyanoethylmercapturic acid (CEMA); cigarette smoking; exposure
Categories
Funding
- British American Tobacco
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Acrylonitrile is an IARC class 2B carcinogen present in cigarette smoke. Urinary 2-cyanoethylmercapturic acid (CEMA) is an acrylonitrile metabolite and a potential biomarker for acrylonitrile exposure. The objective of this work was to study the dose response of CEMA in urine of non-smokers and smokers of different ISO tar yield cigarettes. We observed that smokers excreted >100-fold higher amounts of urinary CEMA than non-smokers. The CEMA levels in smokers were significantly correlated with ISO tar yield, daily cigarette consumption, and urinary biomarkers of smoke exposure. In conclusion, urinary CEMA is a suitable biomarker for assessing smoking-related exposure to acrylonitrile.
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