Journal
BIOMARKERS
Volume 15, Issue 5, Pages 470-474Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2010.485332
Keywords
Cervical cancer; HPV; AKNA; AT-hook motif; SNPs; risk factor; RFLP
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Funding
- Instituto Nacional de Salud Publica
- SEP-CONACyT [46151]
- CONACyT
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The AKNA gene is part of the 9q32 susceptibility locus for cervical cancer. A single-nucleotide polymorphism at codon 1119 of AKNA, yields a biologically relevant amino acid change (R1119Q) at the DNA binding AT-hook motif. Genotype frequencies in 97 allele pairs were: R/R = 0.597, R/Q = 0.278, Q/Q = 0.123. Q/Q homozygosity was present in 8.33% of healthy controls, 16.67% of patients with cervical intraepithelial neoplasia and 75% of cervical cancer patients. These differences are highly significant for the presence of Q/Q in cervical cancer (p = 0.01, odds ratio 3.66, 95% confidence interval 1.35-9.94). Therefore, AKNA appears to be an important genetic factor associated with the risk cervical cancer.
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