Journal
BIOMARKERS
Volume 15, Issue 7, Pages 563-574Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2010.495786
Keywords
Follistatin; bones; transforming growth factor-beta; activin; bone morphogenetic proteins
Categories
Ask authors/readers for more resources
Follistatin is a monomeric glycoprotein, distributed in a wide range of tissues. Recent work has demonstrated that this protein is a pluripotential molecule that has no structural similarity but is functionally associated with members of the transforming growth factor (TGF)-beta superfamily, which indicates its wide range of action. Members of the TGF-beta superfamily, especially activins and bone morphogenetic proteins are involved in bone metabolism. They play an important role in bone physiology, influencing bone growth, turnover, bone formation and cartilage induction. As follistatin is considered to be the antagonist of the TGF-beta-superfamily members, it plays an important role in bone metabolism and development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available