Journal
BIOMARKERS
Volume 15, Issue 4, Pages 297-306Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/13547501003624512
Keywords
Diagnostics; mass spectrometry; foetor hepaticus; fatty liver; exhalation
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Funding
- Kompetenzzentrum Medizin Tirol (KMT) [09]
- Verein zur Forderung wissenschaftlicher Arbeit in Gastroenterologic und Hepatologic in Innsbruck
- Austrian GEN-AU
- Medical School of Heidelberg
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Breath composition is altered in liver diseases. We tested if ion-molecule-reaction mass spectrometry (IMR-MS) combined with a new statistical modality improves the diagnostic accuracy of breath analysis in liver diseases. We analysed 114 molecules in the breath of 126 individuals (healthy controls, and patients with non-alcoholic and alcoholic fatty liver disease and liver cirrhosis) by IMR-MS. Characteristic exhalation patterns were identified for each group. Combining two to seven molecules in the new stacked feature ranking model reached a diagnostic accuracy (area under the curve) for individual liver diseases between 0.88 and 0.97. IMR-MS followed by sophisticated statistical analysis is a promising tool for liver diagnostics by breath analysis.
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