Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 200, Issue 1, Pages 67-72Publisher
ELSEVIER
DOI: 10.1016/S0378-5173(00)00343-4
Keywords
silicified microcrystalline cellulose; mechanical property; strength
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The mechanical properties of compacts of unlubricated microcrystalline cellulose and silicified microcrystalline cellulose were evaluated using the diametric tensile test. The results suggested that, under comparable testing conditions, compacts of silicified microcrystalline cellulose exhibited greater strength than those of microcrystalline cellulose. In addition to enhanced strength, silicified microcrystalline cellulose compacts exhibited greater stiffness and required considerably more energy for tensile failure to occur. Comparison of the data with that obtained for a dry blend of silicon dioxide/microcrystalline cellulose suggested that the functionality benefits of silicification were not due to a simple composite material model. (C) 2000 Elsevier Science B.V. All rights reserved.
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