Journal
BIOMARKERS
Volume 15, Issue 2, Pages 175-182Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/13547500903411087
Keywords
Dyspnea; heart failure; diagnosis; natriuretic peptides; biomarkers; chest radiograph
Categories
Funding
- Roche Diagnostics
- SiemensDiagnostics
- Critical Diagnostics
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To define more clearly the relationship between the information provided by the chest radiograph (CXR) and the natriuretic peptide (NT-proBNP) test as part of the evaluation of dyspneic patients presenting to the emergency department with suspected acute heart failure (HF), we evaluated the PRIDE cohort of 599 patients with and without HF, focusing on blinded NT-proBNP and unblinded CXR information. Clinical characteristics and diagnostic performance for each test were compared. We found that NT-proBNP measurement is superior to routine CXR interpretation for diagnosis or exclusion of acute HF and that normal CXR results should not be used to exclude HF in this population.
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