Journal
NEUROREPORT
Volume 11, Issue 6, Pages 1153-1158Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200004270-00003
Keywords
brain atrophy; demyelination; depression; MRI; multiple sclerosis; white matter disease
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It is unclear whether brain MRI lesions are associated with depression in multiple sclerosis (MS). Neurological dysfunction in depressed (n = 19) and non-depressed (n = 29) MS patients was rated by expanded disability status scale (EDSS). EDSS was weakly predictive of the presence of (P = 0.03) and severity of (p = 0.01) depression. After correcting for EDSS, the presence of depression was predicted by superior frontal and superior parietal hypointense T1 lesions (p< 0.01); the severity of depression was predicted by superior frontal, superior parietal and temporal T1 lesions, lateral and third ventricular enlargement, and frontal atrophy (p < 0.01). Depression was not related to bright T2 lesions or enhancement. We conclude that atrophy and cortical-subcortical disconnection due to frontal and parietal white matter destructive lesions may contribute to depression in MS. NeuroReport 11:1153-1158 (C) 2000 Lippincott Williams & Wilkins.
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