Journal
DNA RESEARCH
Volume 7, Issue 2, Pages 111-120Publisher
UNIVERSAL ACADEMY PRESS INC
DOI: 10.1093/dnares/7.2.111
Keywords
G proteins; BACs; gene structure; chromosome location
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Funding
- NHGRI NIH HHS [HG01464] Funding Source: Medline
- NIGMS NIH HHS [GM34236] Funding Source: Medline
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Heterotrimeric guanine nucleotide binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. Each subunit of the G protein complex is encoded by a member of one of three corresponding gene families. Currently, 16 different members of the alpha subunit family, 5 different members of the beta subunit family, and 11 different members of the gamma subunit family have been described in mammals. Here we have identified and characterized Bacterial Artificial Chromosomes (BACs) containing the human homologs of each of the alpha, beta, and gamma subunit genes as well as a G alpha 11 pseudogene and a previously undiscovered G gamma 5-like gene. The gene structure and chromosome location of each gene was determined, as were the orientations of paired genes. These results provide greater insight into the evolution and functional diversity of the mammalian G protein subunit genes.
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