Journal
TETRAHEDRON
Volume 56, Issue 18, Pages 2879-2888Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(00)00143-5
Keywords
asymmetric induction; addition reactions; oxazolines; copper and compounds
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A series of new P,N-ligands with a binaphthyl and an oxazoline moiety were prepared, which are efficient ligands for the enantioselective copper-catalyzed 1,4-addition of organozinc reagents to enones. Increasing the steric bulk in the 3,3'-position of binaphthyl from an H to a biphenylyl moiety improved the ee from 65 to 94% in the reaction of diethylzinc with cyclopentenone. (C) 2000 Elsevier Science Ltd. All rights reserved.
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