Journal
LANCET
Volume 355, Issue 9214, Pages 1518-1519Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0140-6736(00)02169-3
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- NIDDK NIH HHS [DK-48373] Funding Source: Medline
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We identified zonulin, a novel human protein analogue to the Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in nonhuman primate intestinal epithelia. Zonulin expression was raised in intestinal tissues during the acute phase of coeliac disease, a clinical condition in which tight junctions are opened and permeability is increased.
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