Journal
BIOMACROMOLECULES
Volume 16, Issue 1, Pages 219-227Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm501438e
Keywords
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Funding
- Modality Xn program of Kyoto University/Canon joint research project-Innovative Techno-Hub for Integrated Medical Bio-Imaging from MEXT Budget for the Promotion of Science and Technology
- Ministry of Education, Culture, Sports, Science, and Technology, Japan [2401]
- Grants-in-Aid for Scientific Research [25102523, 26708024] Funding Source: KAKEN
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Amphiphilic hyaluronic acid (HA) derivatives bearing hydrophobic indocyanine green dye derivatives and hydrophilic poly(ethylene glycol) were synthesized through the use of condensation and copper-catalyzed click cyclization reactions. The amphiphilic HA derivatives dissolved in water and formed self-assemblies in which the near-infrared dyes were tightly packed and arranged to form dimers or H-aggregates. By irradiating an aqueous solution of HA derivatives with near-infrared light, photoacoustic signals were detected along with fluorescence emission. Self-assemblies consisting of HA derivatives could smoothly accumulate in tumor tissues by passive tumor targeting. By utilizing HA derivatives as a contrast agent, tumor sites were clearly visualized by optical imaging as well as by photoacoustic tomography.
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