Journal
BIOMACROMOLECULES
Volume 15, Issue 4, Pages 1498-1506Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm5001444
Keywords
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Funding
- University of Nottingham, Faculty of Engineering
- Engineering and Physical Sciences Research Council [EP/J015687/1]
- EPSRC [EP/J015687/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/J015687/1] Funding Source: researchfish
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Polylactic acid (PLA) fibers were produced with an average diameter of 11.2 (+/- 0.9) mu m via a melt-drawing process. The surface of the PLA fibers was coated with blends of cellulose nanowhiskers (CNINs) (65 to 95 wt %) and polyvinyl acetate (PVAc). The CNWs bound to the smooth PLA fiber surface imparted roughness, with the degree of roughness depending on the coating blend used. The fiber tensile modulus increased 45% to 7 GPa after coating with 75 wt % CNINs compared with the uncoated PLA fibers, and a significant increase in the fiber moisture absorption properties at different humidity levels was also determined. Cytocompatibility studies using NIH-3T3 mouse fibroblast cells cultured onto CNWs-coated PLA surface revealed improved cell adhesion compared with the PLA control, making this CNW surface treatment applicable for biomedical and tissue engineering applications. Initial studies also showed complete cell coverage within 2 days.
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