Journal
BIOMACROMOLECULES
Volume 14, Issue 10, Pages 3706-3712Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm401086d
Keywords
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Funding
- NIH [1DP2OD007246]
- NSF [DMR 1309525]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1309525] Funding Source: National Science Foundation
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We developed camptothecin (CPT)-conjugated, core-cross-linked (CCL) micelles that are subject to redox-responsive cleavage of the built-in disulfide bonds, resulting in disruption of the micellar structure and rapid release of CPT. CCL micelles were prepared via coprecipitation of disulfide-containing CPT-poly(tyrosine(alkynyl)-OCA) conjugate and monomethoxy poly(ethylene glycol)-b-poly(tyrosine(alkynyl)-OCA), followed by cross-linking of the micellar core via azide-alkyne click chemistry. CCL micelles exhibited excellent stability under physiological conditions, while they underwent rapid dissociation in reduction circumstance, resulting in burst release of CPT. These redox-responsive CCL micelles showed enhanced cytotoxicity against human breast cancer cells in vitro.
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