Journal
BIOMACROMOLECULES
Volume 14, Issue 2, Pages 431-437Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm3016658
Keywords
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Funding
- MICINN of Spain [CTQ2008-01694]
- MINECO of Spain [CTQ2011-23410, CTQ2011-24652, Consolider-Ingenio CSD2007-00010]
- CAM [MADRISOLAR-2 S2009/PPQ-1533]
- EU [PITN-GA-2008-213592]
- Instituto de Salud Carlos III [FIS01101580]
- European FEDER fund
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Water-soluble glycofullerenes based on a hexakis-adduct of [60]fullerene with an octahedral addition pattern are very attractive compounds providing a spherical presentation of carbohydrates. These tools have been recently described and they have been used to interact with lectins in a multivalent manner. Here, we present the use of these glycofullerenes, including new members with 36 mannoses, as compounds able to inhibit a DC-SIGN-dependent cell infection by pseudotyped viral particles. The results obtained in these experiments demonstrate for the first time that these glycoconjugates are adequate to inhibit efficiently an infection process, and therefore, they can be considered as very promising and interesting tools to interfere in biological events where lectins such as DC-SIGN are involved.
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