Journal
BIOMACROMOLECULES
Volume 14, Issue 5, Pages 1262-1267Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm4003199
Keywords
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Funding
- DMRDP (DoD) [W81XWH1120073]
- NSF [DMR 09-69301]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [969301] Funding Source: National Science Foundation
- U.S. Department of Defense (DOD) [W81XWH1120073] Funding Source: U.S. Department of Defense (DOD)
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Poly(ethylene glycol) (PEG)-based star polymers with a cationic core were prepared by atom transfer radical polymerization (ATRP) for in vitro nucleic acid (NA) delivery. The star polymers were synthesized by ATRP of 2-(dimethylamino)ethyl methacrylate (DMAEMA) and ethylene glycol dimethacrylate (EGDMA). Star polymers were characterized by gel permeation chromatography, zeta potential, and dynamic light scattering. These star polymers were combined with either plasmid DNA (pDNA) or short interfering RNA (siRNA) duplexes to form polyplexes for intracellular delivery. These polyplexes with either siRNA or pDNA were highly effective in NA delivery, particularly at relatively low star polymer weight or molar ratios, highlighting the importance of NA release in efficient delivery systems.
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