Journal
MOLECULAR MICROBIOLOGY
Volume 36, Issue 3, Pages 630-637Publisher
WILEY
DOI: 10.1046/j.1365-2958.2000.01882.x
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Funding
- NIAID NIH HHS [AI44856] Funding Source: Medline
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Members of the Mycobacterium tuberculosis group synthesize a family of long-chain fatty acids, mycolic acids, which are located in the cell envelope. These include the non-oxygenated alpha-mycolic acid and the oxygenated keto- and methoxymycolic acids. The function in bacterial virulence, if any, of these various types of mycolic acids is unknown. We have constructed a mutant strain of M. tuberculosis with an inactivated hma (cmaA, mma4) gene; this mutant strain no longer synthesizes oxygenated mycolic acids, has profound alterations in its envelope permeability and is attenuated in mice.
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