Journal
JOURNAL OF VIROLOGY
Volume 74, Issue 10, Pages 4894-4897Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.74.10.4894-4897.2000
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We report that lysosomotropic agents and cysteine protease inhibitors inhibited protease resistant prion protein accumulation in scrapie-infected neuroblastoma cells. The inhibition occurred without either apparent effects on normal prion protein biosynthesis or turnover or direct interactions with prion protein molecules. The findings introduce two new classes of inhibitors of the formation of protease-resistant prion protein.
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