Journal
BIOMACROMOLECULES
Volume 14, Issue 3, Pages 644-653Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm301703x
Keywords
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Funding
- J.P. Bickell Foundation (Medical Research Grant)
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Ontario Ministry of Research and Innovation
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Injectable, in situ-gelling magnetic composite materials have been fabricated by using aldehyde-functionalized dextran to cross-link superparamagnetic nanoparticles surface-functionalized with hydrazide-functionalized poly(N-isopropylacrylamide) (pNIPAM). The resulting composites exhibit high water contents (82-88 wt.%) while also displaying significantly higher elasticities (G' >60 kPa) than other injectable hydrogels previously reported. The composites hydrolytically degrade via slow hydrolysis of the hydrazone cross-link at physiological temperature and pH into degradation products that show no significant cytotoxicity. Subcutaneous injections indicate only minor chronic inflammation associated with material degradation, with no fibrous capsule formation evident. Drug release experiments indicate the potential of these materials to facilitate pulsatile, on-demand changes in drug release upon the application of an with oscillating magnetic field. The injectable but high-strength and externally triggerable nature of these materials, coupled with their biological degradability and inertness, suggest potential biological applications in tissue engineering and drug delivery.
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