Journal
JOURNAL OF INFECTION
Volume 40, Issue 3, Pages 262-266Publisher
W B SAUNDERS CO LTD
DOI: 10.1053/jinf.2000.0656
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Objectives: To determine the sensitivity and specificity of a novel antibody test for the diagnosis of intravascular catheter-related infections due to coagulase-negative staphylococci. Methods: Sixty-seven patients diagnosed as having central venous catheter (CVC)-associated sepsis based on strict clinical criteria, including positive blood cultures, were compared to 67 patients with a CVC in situ who exhibited no evidence of sepsis, fin ELISA serological test based on a novel short-chain Lipoteichoic acid antigen isolated from congulase-negative staphylococci (CNS) was used to determine the patient's serological response (IgG and IgM) to CVC sepsis caused by CNS, The specificity and sensitivity of the test was determined. Results: There was a significant increase in the antibody levels (IgG and IgM) to the short-chain lipeteichoic acid in patients with CVC-associated staphylococcal sepsis as compared to the control patients, Conclusions: This nerv serological method may. offer a useful diagnostic test for intravascular catheter infections caused by staphylococci. (C) 2000 The British Infection Society.
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