Journal
VETERINARY PATHOLOGY
Volume 37, Issue 3, Pages 278-282Publisher
SAGE PUBLICATIONS INC
DOI: 10.1354/vp.37-3-278
Keywords
C-cell carcinoma; ferrets
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Funding
- NCRR NIH HHS [RR07036] Funding Source: Medline
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A firm, infiltrative mass was found in the thyroid region of an adult castrated male ferret (Mustela putorius) presenting with vague signs of weight loss, minor inappetence, and decreased activity. Efforts to surgically excise the tissue were unsuccessful, and the animal was euthanatized. Gross and histopathologic evaluation revealed multiple endocrine neoplasms, including C-cell carcinoma, adrenocortical adenoma, pheochromocytoma, and endocrine tumor of the pancreas. This is the first descriptive account of a C-cell carcinoma, also known as medullary thyroid carcinoma, in a ferret, although other endocrine neoplasms in this species have been reported with some frequency. These findings mimic features observed in human multiple endocrine neoplasia syndromes.
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