Journal
BIOMACROMOLECULES
Volume 13, Issue 11, Pages 3533-3541Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm3008633
Keywords
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Funding
- National Institute of Health
- Wallace H. Coulter Foundation
- Juvenile Diabetes Research Foundation International
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Novel biodegradable, polymeric nanoparticles composed of beta-cyclodextrin and poly(beta-amino ester) segments have been developed for sustained drug delivery across the. blood-brain barrier (BBB) The nanoparticles have, been synthesized by cross-linking beta-cyclodextrin with poly(beta-amino ester) via the Michael addition Method. The chemical, physical, and degradation properties of the nanoparticles. have been characterized by matrix-assisted laser desoption/ionization time-of-flight, attenuated total reflectance Fourier transform infrared spectroscopy, nuclear Magnetic resonance dynamic light scattering, and atomic force microscopy techniques. Bovine and human brain microvascular endothelial cell monolayers have been constructed as in vitro BBB models. Preliminary results show that the nanoparticles do not affect the integrity of the in vitro BBB models, and the nanoparticles have much higher permeability than dextran control across the in vitro BBB models. Doxorubicin has been loaded into the nanoparticles With a loading efficiency of 86%, and can be released from the nanoparticles. for at least one month The developed beta-cyclodextrin-poly(beta-amino ester) nanoparticles might be useful as drug carriers for transporting drugs across the BBB to treat chronic diseases in the brain.
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