Journal
BIOMACROMOLECULES
Volume 13, Issue 8, Pages 2465-2471Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm300707a
Keywords
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Funding
- NSF [1150768]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1150768] Funding Source: National Science Foundation
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Biocompatible photoresponsive materials are of interest for targeted drug delivery, tissue engineering, 2D and 3D protein patterning, and other biomedical applications. We prepared light degradable hydrogels using a natural alginate polysaccharide cross-linked with iron(III) cations. The hard iron(III) cations used to cross-link the alginate hydrogel were found to undergo facile photoreduction to soft iron(II) cations in the presence of millimolar concentrations of sodium lactate. The soft iron(II) cations have a decreased ability to cross-link the alginate which results in dissolution of the hydrogel and the formation of a homogeneous solution. The photodegradation is done using long wave UV or visible light at neutral pH. The very mild conditions required for the photodegradation and the high rate at which it occurs suggest applications for iron(III) cross linked alginate hydrogels as light controlled biocompatible scaffolds.
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