Journal
BIOMACROMOLECULES
Volume 13, Issue 3, Pages 896-904Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm201812u
Keywords
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Funding
- Region Aquitaine
- GIS Advanced Materials in Aquitaine
- Agence Nationale pour la Recherche (ANR)
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This work reports on the synthesis of titanium bone implants functionalized with nanoparticles (NPs) containing Arg-Gly-Asp-Cys peptide (RGDC) and shows the adhesion behavior of cells seeded on these materials. RGDC peptides were first: conjugated to a norbornenyl-poly(ethylene oxide) macromonomer (Nb-PEO). Then, functional NPs with a size of similar to 300 nm and constituted of polynorbornene core surrounded by poly(ethylene oxide) shell were prepared by ring-opening metathesis polymerization in dispersed medium. The grafting density of these NPs on the titanium surface is up to 2 NPs.mu m(-2) (80 pmol of RGDC per cm(-2) of NP surface). Cell adhesion was evaluated using preosteoblast cells (MC3T3-E1). Results of cells cultured for 24 h showed that materials grafted with NPs functionalized with RGDC peptides enhance specific cell adhesion and can create filopodia-like among NP sites by stressing the cells.
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