Journal
BIOMACROMOLECULES
Volume 13, Issue 8, Pages 2333-2338Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm300578p
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Funding
- NIH [CA112085, GM60938]
- W.M. Keck Foundation
- Skaggs Institute for Chemical Biology
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Virus-like particles (VLPs) have proven to be versatile platforms for chemical and genetic functionalization for a variety of purposes in biomedicine, catalysis, and materials science. We describe here the simultaneous modification of the bacteriophage Q beta VLP with a metalloporphyrin derivative for photodynamic therapy and a glycan ligand for specific targeting of cells bearing the CD22 receptor. This application benefits from the presence of the targeting function and the delivery of a high local concentration of singlet Oxygen-generating payload.
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