Journal
BIOLOGICAL CHEMISTRY
Volume 381, Issue 5-6, Pages 453-456Publisher
WALTER DE GRUYTER & CO
DOI: 10.1515/BC.2000.059
Keywords
GTPase-activating protein; secretion; vesicular transport; yeast; Ypt/Rab GTPase
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Ypt/Rab proteins of the Has superfamily are regulators of protein transport in exo- and endocytosis. Like pas and Rho proteins, they have a slow intrinsic GTPase activity that can be accelerated by several orders of magnitude by GTPase-activating proteins (GAP). Here we describe a new member of a family of Ypt/Rab-specific GAPs, Msb4p/Gyp4p, that shares with other Gyp family members significant homology in the catalytic domain, recently identified in Gyp1p and Gyp7p. Purified Msb4p/Gyp4p acts primarily on Sec4p, Ypt6p and Ypt7p and might have a role in polarized secretion.
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