Journal
BIOMACROMOLECULES
Volume 13, Issue 8, Pages 2219-2224Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm300646q
Keywords
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Funding
- National Science Foundation [DM 1006711D]
- Howard Hughes Medical Institute
- National Institute of Health [T32 GM-065103]
- Teets Family Endowed Doctoral Fellowship
- UROP (UC-Boulder)
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1006711] Funding Source: National Science Foundation
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We describe here light-regulated swelling and degradation features of polymeric nanoparticles that are produced using an inverse microemulsion polymerization method. We demonstrate the phototriggered release characteristics of the nanoparticles by sequestering protein molecules and releasing them using light as a trigger. Furthermore, the intracellular translocation of the nanoparticles, along with its fluorescent protein payload, was achieved using a cell penetrating peptide based surface modification. We expect that the noncovalent encapsulation of proteins using nanoparticles and their photo triggered release using an external light would provide opportunities for achieving intracellular release of molecular therapeutics for on-demand requirements.
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