Journal
BIOMACROMOLECULES
Volume 12, Issue 2, Pages 336-341Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm101031a
Keywords
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Funding
- Ministry of Education, Science, and Technology [2010-0004806]
- Ministry of Education, Science Technology (MEST)
- Korea Institute for Advancement of Technology (KIAT)
- National Research Foundation of Korea [2010-0004806] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Blood compatible graphene/heparin conjugate is simply formulated through noncovalent interaction between chemically reduced graphene and heparin. Charge repulsion of negatively charged heparin on graphene plates renders hydrophobic graphene to be solublized in aqueous media without any precipitation or aggregation even after 6 months. Unfractioned heparin (UFH) with higher molecular weight was effective for graphene solubilization while low molecular weight heparin (LMWH) was not. Noncovalently interacting heparin chains on graphene plates preserve their anticoagulant activity after conjugation with graphene. Graphene/UFH conjugate shows much enhanced anti factor Xa (FXa) activity of 29.6 IU/mL compared with pristine graphene oxide (GO; 1.03 IU/mL).
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