Journal
BIOMACROMOLECULES
Volume 12, Issue 7, Pages 2653-2659Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm200464x
Keywords
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Funding
- WCU [R31-10071]
- Molecular-Level Interface Research Center [2011-0001319]
- Ministry of Education, Science and Technology, Republic of Korea [2010-0028765]
- National Research Foundation of Korea [R31-2011-000-10071-0, 2009-0093117, 2009-0092222] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Bioinspired from adhesion behaviors of mussels, injectable and thermosensitive chitosan/Pluronic composite hydrogels were synthesized for tissue adhesives and hemostatic materials. Chitosan conjugated with multiple catechol groups in the backbone was cross-linked with terminally thiolated Pluronic F-127 triblock copolymer to produce temperature-sensitive and adhesive sol-gel transition hydrogels. A blend mixture of the catechol-conjugated chitosan and the thiolated Pluronic F-127 was a viscous solution state at room temperature but became a cross-linked gel state with instantaneous solidification at the body temperature and physiological pH. The adhesive chitosan/Pluronic injectable hydrogels with remnant catechol groups showed strong adhesiveness to soft tissues and mucous layers and also demonstrated superior hemostatic properties. These chitosan/Pluronic hydrogels are expected to be usefully exploited for injectable drug delivery depots, tissue engineering hydrogels, tissue adhesives, and antibleeding materials.
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