Journal
BIOMACROMOLECULES
Volume 12, Issue 10, Pages 3528-3539Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm200718s
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Funding
- North Carolina State University
- Finnish Funding Agency for Technology and Innovation
- Tekes
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Adherence and survival of pathogenic bacteria on surfaces leading to concomitant transmission to new hosts significantly contributes to the proliferation of pathogens, which in turn considerably increases the threat to human health, particularly by antibiotic-resistant bacteria. Consequently, more research into effective surface disinfection and alternative materials (fabrics, plastics, or coatings) with,antimicrobial and other bioactive characteristics is desirable. This report describes. the synthesis and characterization Of cellulose nanocrystals that were surface-modified with a cationic porphyrin. The porphyrin was appended onto the cellulose surface via the Cu(I)-catalyzed Huisgen-Meldal-Sharpless 1,3-dipolar cycloaddition having occurred between azide groups on the cellulosic surface and porphyrinic alkynes. The resulting, generally insoluble, crystalline material CNC-Por (5), was characterized by infrared and diffusion H-1 NMR spectroscopies, gel permeation chromatography, and thermogravimetric analysis. Although only suspended, and not dissolved, in an aqueous system, CNC-Por (5) showed, excellent efficacy toward the photodynamic inactivation of Mycobacterium smegmatis and Staphylococcus aureus, albeit only slight activity against Escherichia coli. The synthesis, properties, and activity of CNC-por (5) described herein serve as a benchmark toward our overall objectives of developing novel, potent, bioactive, photobactericidal materials that are effective against a range of bacteria, with potential utilization in the health care and food preparation industries.
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