Journal
PARASITE IMMUNOLOGY
Volume 22, Issue 5, Pages 223-230Publisher
WILEY
DOI: 10.1046/j.1365-3024.2000.00302.x
Keywords
Theileria annulata; Theileria parva; sporozoite antigen; vaccine; cross-protection
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Theileria annulata and Theileria parva both possess a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These antigens share sequence homology and are serologically cross-reactive. Here, we confirm that these antigens confer protection against homologous species challenge. More importantly, they mutually confer a degree of cross-species protection raising the prospect of a common vaccine in the future.
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