Journal
BIOMACROMOLECULES
Volume 12, Issue 5, Pages 1585-1593Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm101584c
Keywords
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Funding
- USDA/CSREES [2005-35504-16088]
- National Science Foundation [CHE-0724126, DMR-0907567]
- Institute for Critical Technology and Applied Science at Virginia Tech.
- Omnova
- Tembec
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [0907567] Funding Source: National Science Foundation
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This study examines a novel polyelectrolyte-macroion complex (PMC) between chitosan, a cationic polysaccharide, and cellulose nanocrystals (CNCs), anionic, cylindrical nanoparticles, for potential applications in drug delivery. CNCs were prepared by H2SO4 hydrolysis of wood pulp. The formation of PMCs was monitored by turbidimetric titration. In titrations of a chitosan solution with a CNC suspension, the turbidity reached a plateau, but it had a maximum and then decreased when the direction of titration was reversed. PMC particles were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, dynamic light scattering, and laser Doppler electrophoresis. The particles were composed primarily of CNCs and ranged in size from a few hundred nanometers to several micrometers, depending on the cellulose/chitosan ratio. Particles formed at amino/sulfate group molar ratios > 1 were nearly spherical in shape and positively charged, whereas particles formed at ratios < 1 had well-defined nonspherical shapes and were negatively charged.
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