Journal
BIOMACROMOLECULES
Volume 12, Issue 9, Pages 3232-3242Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm2007086
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Funding
- Grant Agency of the Academy of Sciences of Czech Republic [KJB400500904]
- Czech Science Foundation [P108/11/1857, P207/10/P569]
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In this study, we propose substrate-independent modification for creating a protein-repellent surface based on dopamine melanin anchoring layer used for subsequent binding of poly(ethylene oxide) (PEO) from melt. We verified that the dopamine-metanin layer can be formed on literally any substrate and could serve as the anchoring layer for subsequent grafting of PEO chains. Grafting of PEO from melt in a temperature range 70-110 degrees C produces densely packed PEO layers showing exceptionally low protein adsorption when exposed to the whole blood serum or plasma. The PEO layers prepared from melt at 110 degrees C retained the protein repellent properties for as long as 10 days after their exposure to physiological-like conditions. The PEO-cloparnine-melanin modification represents a simple and univearsal surface modification method for the preparation of,, protein repellent surfaces that could serve as a nonfouling background in Various applications, such as optical biosensors and tissue engineering.
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