Journal
BIOMACROMOLECULES
Volume 12, Issue 10, Pages 3453-3459Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm2005752
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Funding
- Nokia Research
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Amyloid nanofibers derived from hen egg white lysozyme were processed into macroscopic fibers in a wet-spinning process based on interfacial polyion complexation using a polyanionic polysaccharide as cross-linker. As a result of their amyloid nanostructure, the hierarchically self-assembled protein fibers have a stiffness of up to 14 GPa and a tensile strength of up to 326 MPa. Fine tuning of the polyelectrolytic interactions via pH allows to trigger the release of small molecules, as demonstrated with riboflavin 5' phophate. The amyloid fibrils, highly oriented within the gellan gum matrix, were mineralized with calcium phosphate, mimicking the fibrollamellar structure of bone. The formed mineral. crystals are highly oriented along the nanofibers, thus resulting in a 9-fold increase in fiber stiffness.
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