Journal
BIOMACROMOLECULES
Volume 12, Issue 6, Pages 1983-1986Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm2006054
Keywords
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Funding
- Australian Research Council [DP0986043, DP0985694]
- National Basic Research Program of China [2009CB918304]
- Chinese 111 project (China) [B06018]
- Knut and Alice Wallenberg Foundation (Sweden)
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Glycogen is a highly branched glucose polymer functioning as a glucose buffer in animals. Multiple-detector size exclusion chromatography and fluorophore-assisted carbohydrate electrophoresis were used to examine the structure of undegraded native liver glycogen (both whole and enzymatically del;ranched) as a function of molecular size, isolated from the liver; of healthy and db/db mice (the latter a type 2 diabetic model). Both the fully branched and debranched levels of glycogen structure showed fundamental differences between glycogen from healthy and db/db mice. Healthy glycogen had a greater population of large particles, with more a particles (tightly linked assemblages of smaller,8 particles) than glycogen from db/db mice. These structural differences suggest a new understanding of type 2 diabetes.
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