Journal
BIOMACROMOLECULES
Volume 12, Issue 8, Pages 2908-2913Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm200469a
Keywords
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Funding
- DST, New Delhi, India [INT/SWISS/RF, JUAF/2008]
- EPFL, Switzerland [INT/SWISS/RF, JUAF/2008]
- EU [NMP4-CT2006-026723]
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Herein the concept of tandem postpolymerization modification as a versatile route to synthesize well-defined, highly functionalized polymers is introduced. Poly(pentafluorophenyl methacrylate) obtained by atom transfer radical polymerization was first modified with allylamine, which displaces the active ester to give well-defined polymers with pendant alkene groups, which are difficult to obtain by direct (radical) polymerization of allylic-functional monomers. The produced poly(allylmethacrylamide) was modified by a second postpolymerization modification reaction with a thiol-terminated peptide (CVPGVG) using AIBN as the radical source. NMR, IR, and SEC demonstrated successful conjugation onto the polymer to give a polymer-peptide hybrid material. This versatile strategy should extend the scope of controlled radical polymerization and click-type reactions
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