Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 49, Issue 3, Pages 237-242Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0939-6411(00)00077-1
Keywords
solid dispersions; melt extrusion; tablets; 17 beta-estradiol hemihydrate; polymers; poorly soluble drugs
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17 beta-Estradiol hemihydrate (17 beta-E2) is a poorly water-soluble drug. Physical methods for improving the solubility and dissolution rate, e.g. micronization, have certain inherent disadvantages. The method of choice in this study, melt extrusion, proved to overcome many of the shortcomings of conventional methods. Different compositions of excipients such as PEG 6000, PVP (Kollidon((R)) 30) or a vinylpyrrolidone-vinylacetate-copolymer (Kollidon((R)) VA64) were used as polymers and Sucroester((R)) WE15 or Gelucire((R)) 44/14 as additives during melt extrusion. The solid dispersions resulted in a significant increase in dissolution rate when compared to the pure drug or to the physical mixtures. For example, a 30-fold increase in dissolution rate was obtained for a formulation containing 10% 17 beta-E2, 50% PVP and 40% Gelucire((R)) 44/14. The solid dispersions were then processed into tablets. The improvement in the dissolution behavior was also maintained with the tablets. The USP XXIII requirement for estradiol tablets reaching greater than 75% drug dissolved after 60 min was obtained in this investigation. (C) 2000 Elsevier Science B.V. All rights reserved.
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