Journal
BIOMACROMOLECULES
Volume 12, Issue 4, Pages 1205-1213Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm1014987
Keywords
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Funding
- Junta de Comunidades de CastillaLa Mancha [PCI08-0033, PII1I09-0163-4002, POII10-0274-3182]
- Fondo de Investigaciones Sanitarias
- Ministerio de Ciencia e Innovacion
- Ministerio de Ciencia e Innovacion (Spain)
- NanoDrugs
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A novel hybrid dendrimer (TRANSGEDEN) that combines a conjugated rigid polyphenylenevinylene (PPV) core with flexible polyamidoamine (PAMAM) branches at the surface was synthesized and characterized. The potential of this material as a nonviral gene delivery system was also examined, and it was observed that dendriplexes formed by TRANSGEDEN and small interfering ribonucleic acids (siRNAs) can be incorporated into >90% of neuronal cells without any toxicity up to a dendrimer concentration of 3 mu M. TRANSGEDEN was used to deliver a specific siRNA to rat cerebellar granular neurons (CGNs) to knock down the cofilin-1 protein. Cofilin-1 removal partially protects CGNs from N-methyl D-aspartate (NMDA)-mediated neuronal death.
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