Journal
BIOMACROMOLECULES
Volume 12, Issue 12, Pages 4196-4203Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm201354m
Keywords
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Funding
- NSF [CHE-0616615, MCB-0516025]
- Arnold and Mabel Beckman Foundation
- HHMI
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Photoelectronically conductive self assembling peptide-porphyrin assemblies have great potential in their use as biomaterials, owing largely to their environmentally responsive properties. We have successfully designed a coiled-coil peptide that can self-assemble to form mesoscale filaments and serve as a scaffold for porphyrin interaction. In our earlier work, peptide-porphyrin-based biomaterials were formed at neutral pH, but the structures were irregular at the nano- to microscale size range, as judged by atomic force microscopy. We identified a pH in which mesoscale fibrils were formed, taking advantage of the types of porphyrin interactions that are present in well-characterized J-aggregates. We used UV-visible spectroscopy, circular dichroism spectropolarimetry, fluorescence spectroscopy, and atomic force microscopy to characterize these self assembling biomaterials. We propose a new assembly paradigm that arises from a set of unique porphyrin-porphyrin and porphyrin-peptide interactions whose structure may be readily modulated by changes in pH or peptide, concentration.
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