Journal
BIOMACROMOLECULES
Volume 12, Issue 11, Pages 3952-3961Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm200965x
Keywords
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Funding
- Portuguese Foundation for Science and Technology [SFRH/BD/64070/2009]
- European NoE EXPERTISSUES [NMP3-CT-2004-500283]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/64070/2009] Funding Source: FCT
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The present work was focused on the development and characterization of new hydrogel systems based on natural origin polymers, namely, alginate and carrageenan, into different formats and with adequate properties to sustain the viability of encapsulated cells, envisioning their application as cell delivery vehicles for tissue regeneration. Different formulations of alginate and carrageenan hydrogels and different processing parameters were considered to determine the best conditions required to achieve the most adequate response in terms of the mechanical stability, cell viability, and functionality of the developed, systems. The morphology, size, and structure of the hydrogels and their degradation behavior and mechanical properties were evaluated during this study. In addition to cytotoxicity studies, preliminary experiments were carried out to investigate the ability of alginate-carrageenan beads/fibers to encapsulate chondrocytes. The results obtained indicated that the different formulations, both in the form of beads and fibers, have considerable potential as cell-carrier materials for cell delivery in tissue engineering/regenerative medicine applications.
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