Journal
BIOMACROMOLECULES
Volume 11, Issue 1, Pages 233-237Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm901082y
Keywords
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Funding
- BMBF [03N8712]
- Volkswagen Foundation
- DFG [SY125/1-1, IO 68/1-1]
- Max-Planck-Society
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We report on the protein-resistant properties of glass substrates coated with novel copolymers of 2-aminoethyl methacrylate hydrochloride and poly(ethylene glycol) methyl ether methacrylate (AEM-PEG). In comparison to currently available protein-blocking polymer systems, such as poly-L-lysine-poly(ethylene glycol), silane-based poly(ethylene glycol), and poly(ethylene glycol) brushes prepared by surface-initiated polymerization, the proposed AEM-PEG offers the combined advantages of low cost, simplicity of use, and applicability in aqueous solutions. We demonstrate the capability of AEM-PEG to block the surface binding of globular proteins (tubulin), their assemblies (microtubules), and functional motor proteins (kinesin-1). Moreover, we demonstrate the applicability of AEM-PEG for surface patterning of proteins in microfluidic devices.
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