Journal
CORNEA
Volume 19, Issue 3, Pages 364-368Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00003226-200005000-00021
Keywords
tranilast; pterygium; fibroblasts; proliferation; chemotaxis; collagen gel contraction; collagen synthesis
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Purpose. We studied the possibility that tranilast, an antiallergic and antiproliferative drug, may be beneficial for the treatment of pterygium. Methods. Pterygium-derived cells were identified by immunohistochemical methods. Growth rate of pterygium-derived cells was determined by using a hemocytometer. Chemotaxis was determined in a microchemotaxis chamber. Pterygium-derived cells were cultured on floating collagen gel, and the contracted diameter was measured. Collagen synthesis by pterygium-derived cells was determined by the collagenase digestive method. Tranilast was added to the culture medium at final concentrations of 0, 12.5, 25, 50, and 100 mu g/ml. Results, Pterygium-derived cells were stained with anti-prolylhydroxylase and anti-alpha-smooth muscle actin, and identified as fibroblasts. Tranilast inhibited the proliferation and chemotaxis of pterygium-derived fibroblasts, and the collagen-gel contraction induced by these cells, but it exerted no inhibitory action on collagen synthesis by pterygium-derived fibroblasts. Conclusion, Tranilast may be useful for suppressing the recurrence and, possibly, the development of pterygium.
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