Journal
PHARMACEUTICAL RESEARCH
Volume 17, Issue 5, Pages 497-504Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/A:1007502828372
Keywords
tissue engineering; growth factors; controlled release; bone; nerve; liver
Funding
- NHLBI NIH HHS [R37-HL18672] Funding Source: Medline
- NIAMS NIH HHS [R29-AR42539] Funding Source: Medline
- NINDS NIH HHS [P01-NS23326] Funding Source: Medline
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A tissue-engineered implant is a biologic-biomaterial combination in which some component of tissue has been combined with a biomaterial to create a device for the restoration or modification of tissue or organ function. Specific growth factors, released from a delivery device or from co-transplanted cells. would aid in the induction of host paraenchymal cell infiltration and improve engraftment of co-delivered cells for more efficient tissue regeneration or ameliorate disease states. The characteristic properties of growth factors are described to provide a biological basis for their use in tissue engineered devices. The principles of polymeric device development for therapeutic growth factor delivery in the context of tissue engineering are outlined. A review of experimental evidence illustrates examples of growth factor delivery from devices such as micropaticles. scaffolds, and encapsulated cells, for their use in the application areas of musculoskeletal tissue, neural tissue, and hepatic tissue.
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