Journal
TRENDS IN MICROBIOLOGY
Volume 8, Issue 5, Pages 238-244Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0966-842X(00)01734-0
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In bacteria, extracellular signals are generally transduced into cellular responses via a two-component system. However, genome sequence data have now revealed the presence-of 'eukaryotic-like' protein kinases and phosphatases. Mycobacterium tuberculosis appears to be unique among bacteria in that its genome contains 11 members of a newly identified protein kinase family. These M. tuberculosis eukaryotic-like protein kinases could be key regulators of metabolic processes, including transcription, cell development and interactions with host cells.
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